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The book series will provide comprehensive and unified presentations of statistical designs and analyses of important applications in biostatistics and bioinformatics, such as those in biological and biomedical research. The scope of the series is wide, including applications of statistical methodology in biology, epidemiology, genetics, pharmaceutical science and clinical trials, public health, and medicine. The series is committed to providing easy to understand, state-of-the-art references and textbooks. In each volume, statistical concepts and methodologies will be illustrated through real world examples whenever possible.

Please contact us if you have an idea for a book for the series. Useful in many areas of medicine and biology, Bayesian methods are particularly attractive tools for the design of clinical trials and diagnostic tests, which are based on established information, usually from related previous studies. Kelly H. Zou, Aiyi Liu, Andriy I. Rockette July 27, Statistical evaluation of diagnostic performance in general and Receiver Operating Characteristic ROC analysis in particular are important for assessing the performance of medical tests and statistical classifiers, as well as for evaluating predictive models or algorithms.

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This book presents The increased use of non-inferiority analysis has been accompanied by a proliferation of research on the design and analysis of non-inferiority studies. Using examples from real clinical trials, Design and Analysis of Non-Inferiority Trials brings together this body of research and confronts the In clinical trial practice, controversial statistical issues inevitably occur regardless of the compliance with good statistical practice and good clinical practice.

But by identifying the causes of the issues and correcting them, the study objectives of clinical trials can be better achieved. As clinicians begin to realize the important role of dose-finding in the drug development process, there is an increasing openness to "novel" methods proposed in the past two decades. Measures of Interobserver Agreement and Reliability, Second Edition covers important issues related to the design and analysis of reliability and agreement studies.

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It examines factors affecting the degree of measurement errors in reliability generalization studies and characteristics influencing The concept of frailty offers a convenient way to introduce unobserved heterogeneity and associations into models for survival data. In its simplest form, frailty is an unobserved random proportionality factor that modifies the hazard function of an individual or a group of related individuals.

Now viewed as its own scientific discipline, clinical trial methodology encompasses the methods required for the protection of participants in a clinical trial and the methods necessary to provide a valid inference about the objective of the trial. Written by leading pioneers Useful Statistical Approaches for Addressing Multiplicity IssuesIncludes practical examples from recent trials Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical industry, academia, and regulatory agencies, Multiple Testing Problems in Pharmaceutical Using WinBUGS to implement Bayesian inferences of estimation and testing hypotheses, Bayesian Methods for Measures of Agreement presents useful methods for the design and analysis of agreement studies.

! Translational Medicine Strategies And Statistical Methods Chapman Hall Crc Biostatistics Series

It focuses on agreement among the various players in the diagnostic process. The author employs Preeminent Experts Update a Well-Respected Book Taking into account the regulatory and scientific developments that have occurred since the second edition, Design and Analysis of Bioavailability and Bioequivalence Studies, Third Edition provides a complete presentation of the latest progress of Stay on CRCPress.

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Conditional Error Function Method. Recursive Adaptive Design.

Adaptive Treatment Switching and Crossover. ResponseAdaptive Allocation Design.

Statistical Methods in Translational Medicine

Adaptive Dose Finding Design. Bayesian Adaptive Design.

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Planning Execution Analysis and Reporting. Paradox Debates in Adaptive Designs. Random Number Generation.

Strategies and Statistical Methods

Implementing Adaptive Designs in R. SampleSize ReEstimation Design. MultipleEndpoint Adaptive Design. DropLoser and AddArm Design.